BizTalk Server 2013 R2 Standard Edition
The R2 update includes other new features in the SB Messaging adapter, the HL7 Accelerator and more, which are listed on this MSDN page. BizTalk Server 2013 R2 can run in the cloud in a virtual machine on Windows Server and/or connect to the cloud in a variety of ways, including via Azure BizTalk Services. Azure BizTalk Services allows users to build enterprise application integration (EAI), EDI (electronic data interchange) and B2B (business-to-business) apps and services on Azure.